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Video Lectures in English
Lecture in Dresden (ECCS 07) on videolectures.net
Over
4500 views
This lecture was given at a Conference on Complex systems
in Dresden. It begins by noting that we do not yet really
know what Systems Biology is. I agree with the following
remark:
"You are
probably running out of patience for some definition of
systems biology. In any case, I do not think the explicit
definition of systems biology should come from me but should
await the words of the first great modern systems biologist.
She or he is probably among us now." (Marc Kirschner,
Harvard University, 2005, Cell, 121, 503-504).
We are all
feeling our way in the face of the extreme complexity of
nature and the daunting task of unraveling her secrets.
Interview in Dresden (ECCS 07) on videolectures.net
This interview followed the Dresden lecture and explains
what the book and the lecture are about.
Lectures in Oxford
on www.pulse-project.org
These lectures on systems biology for a public audience were
accompanied with music, one of them with the renowned
classical guitarist, Christoph Denoth (
http://www.christophdenoth.com )
Lecture in Freiburg
Plenary lecture, "Principles of systems biology and their
application to cells", given at the conference "Systems
Biology of Mammalian Cells" in Freiburg in June 2010:
Where are the cathedrals of the 21st century? They are here
in this room!
Published Lectures & articles (download pdfs)
Paton Lecture (ten principles of
Systems Biology) Principle of Biological Relativity
"There is no
privileged level of causality in biological systems" (The
Music of Life, page xii) This lecture develops
this principle in the context of general principles of
systems biology. Genes and Causation
(relations between genes and phenotype)
Third principle: DNA is not the sole transmitter of
inheritance.
"There are two components to molecular
inheritance: the genome DNA, which can be viewed as digital
information, and the cellular machinery, which can, perhaps
by contrast, be viewed as analogue information."
Biophysics and Systems Biology (why Systems Biology is
revolutionary)
Systems biology and evolution
"Central building blocks of
the neo-Darwinian synthesis are now known to be incompatible
with the most recent discoveries in molecular biology."
"Letter from
Lamarck"
"Lamarckism"??
"There is a widespread perception that
Darwin and Lamarck fought over this issue of the mechanisms
of inheritance" (The Music of Life, page 99). This
brief "Letter from Lamarck" explains why this perception is
profoundly incorrect.
Selfish genes: are they of any use in physiology?
"The selfish gene idea is not useful in the physiological
sciences, since selfishness cannot be defined as an
intrinsic property of nucleotide sequences independently of
gene frequency, i.e. the ‘success’ in the gene pool that is
supposed to be attributable to the ‘selfish’ property. It is
not a physiologically testable hypothesis.
Differential and
Integral views of genetics
"This article uses an
integrative systems biological view of the relationship
between genotypes and phenotypes to clarify some conceptual
problems in biological debates about causality. The
differential (gene-centric) view is incomplete in a sense
analogous to using differentiation without integration in
mathematics."
Published
in the Royal Society journal, Interface Focus, 2011,
1, 7-15
A Theory of Biological relativity
This article has
just appeared on-line in the Royal Society's journal
Interface Focus. Biological relativity can be seen as an
extension of the relativity principle by avoiding the
assumption that there is a privileged scale at which
biological functions are determined. It forms part of an
issue of the journal devoted to downward causation.
Lectures in French
Colloquium Jacques
Morgenstern, INRIA, Sophia Antipolis, April 2007
Launch of La Musique de la Vie, Paris,
January 2007
Congrès GIFRIC,
Québec, May 2008
Concert Lectures
Presented with guitarist Christoph
Denoth
Video recording of Concert-Lecture "The Music of Life" at
Sheffield University | 
